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The research in our group is focussed on the development and application of nuclear magnetic resonance (NMR) spectroscopy to study biomacromolecules. Our focus is to contritube to a molecular understanding of fundamental mechanism of biomacromolecules. We investigate proteins - soluble proteins and membrane proteins. We investige RNAs and RNA-protein complexes and unusual DNA structures.
Particular emphasis is on time-resolved NMR experiments; we induce protein, DNA- or RNA-folding by light from compounds that are caged in one (of several) conformations by photolabile protecting groups or natural light-absorbing chromophors. Some of these caged molecules are synthesized in the lab. A different way of inducing biomacromolecular folding is by temperature jump; thus we have developed T-jump probes to do these kind of experiments.
Particular emphasis is on time-resolved NMR experiments; we induce protein, DNA- or RNA-folding by light from compounds that are caged in one (of several) conformations by photolabile protecting groups or natural light-absorbing chromophors. Some of these caged molecules are synthesized in the lab. A different way of inducing biomacromolecular folding is by temperature jump; thus we have developed T-jump probes to do these kind of experiments.
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Nina M. Krause, Jasleen K. Bains, Julius Blechar,Christian Richter,Irene Bessi,Phillip Grote,Matthias S. Leisegang,Ralf P. Brandes,Harald Schwalbe
CHEMBIOCHEM (2024)
Nadide Altincekic, Nathalie Joeres,Frank Loehr,Christian Richter, Claus Ehrhardt,Marcel J. J. Blommers, Hannes Berg, Sare Oeztuerk, Santosh L. Gande,Verena Linhard,Julien Orts, Marie Jose Abi Saad,
ACS CHEMICAL BIOLOGYno. 2 (2024): 563-574
Xavier Jalencas, Hannes Berg, Ludvik Olai Espeland,Sridhar Sreeramulu, Franziska Kinnen,Christian Richter,Charis Georgiou, Vladyslav Yadrykhinsky,Edgar Specker,Kristaps Jaudzems, Tanja Miletic, Robert Harmel,
BIOspektrumno. 3 (2024): 292-295
ACS CHEMICAL BIOLOGYno. 3 (2024): 607-618
Nadide Altincekic, Nathalie Joeres,Frank Loehr,Christian Richter, Claus Ehrhardt,Marcel J. J. Blommers,Hannes Berg, Sare Oeztuerk,Santosh L. Gande,Verena Linhard,Julien Orts, Marie Jose Abi Saad,
ACS CHEMICAL BIOLOGYno. 2 (2024): 563-574
Chembiochem : a European journal of chemical biologyno. 10 (2024): e202400049-e202400049
Tobias Matzel, Maria Wirtz Martin, Alexander Herr,Anna Wacker,Christian Richter,Sridhar Sreeramulu,Harald Schwalbe
RNA (New York, N.Y.) (2024)
Daniel Hymon,Jason Martins, Christian Richter,Sridhar Sreeramulu, Anna Wacker,Jan Ferner, Neeraj N. Patwardhan, Amanda E. Hargrove,Harald Schwalbe
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