The efficacy and safety of short-course radiotherapy followed by sequential chemotherapy and Cadonilimab for locally advanced rectal cancer: a protocol of a phase II study

Tongzhen Xu,Lingling Feng,Wenjue Zhang, Haoyue Li, Huiying Ma, Muyasha Abulimiti, Yutong Tan, Feiyan Deng,Wenting Huang,Shuangmei Zou, Wenyan Kang,Liming Jiang,Ying Wang,Chen Hu,Yinggang Chen,Haitao Zhou,Yuan Tang,Jing Jin

BMC Cancer（2024）

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摘要

For patients with locally advanced rectal cancer (LARC), total neoadjuvant therapy (TNT), namely, intensifying preoperative treatment through the integration of radiotherapy and systemic chemotherapy before surgery, was commonly recommended as the standard treatment. However, the risk of distant metastasis at 3 years remained higher than 20

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关键词

Locally advanced rectal cancer,Bispecific antibody immunotherapy,Short-course radiotherapy,Total neoadjuvant therapy,Complete response

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