C1q + tumor-associated macrophages contribute to immunosuppression through fatty acid metabolic reprogramming in malignant pleural effusion.

Siyu Zhang,Wenbei Peng,Haolei Wang,Xuan Xiang,Linlin Ye,Xiaoshan Wei,Zihao Wang,Qianqian Xue,Long Chen,Yuan Su,Qiong Zhou

Journal for immunotherapy of cancer（2023）

引用 0|浏览17

暂无评分

摘要

C1q TAMs impede antitumor effects of CD8 T cells promoting MPE immunosuppression. Targeting C1q TAMs effectively alleviates the immunosuppression and enhances the efficacy of ICB therapy. C1q TAMs subset has great potential to be a therapeutic target for cancer immunotherapy.

查看译文

关键词

immunomodulation, immunotherapy, macrophages, tumor microenvironment, lymphocytes, tumor-infiltrating

AI 理解论文

溯源树

样例

生成溯源树，研究论文发展脉络

Chat Paper

正在生成论文摘要