Deep phenotyping and genomic data from a nationally representative study on dementia in India.

Jinkook Lee, Sarah Petrosyan,Pranali Khobragade,Joyita Banerjee,Sandy Chien, Bas Weerman,Alden Gross,Peifeng Hu,Jennifer A Smith,Wei Zhao,Leon Aksman,Urvashi Jain, G S Shanthi, Ravi Kurup, Aruna Raman,Sankha Shubhra Chakrabarti,Indrajeet Singh Gambhir,Mathew Varghese,John P John,Himanshu Joshi,Parvaiz A Koul,Debabrata Goswami,Arunansu Talukdar,Rashmi Ranjan Mohanty,Y Sathyanarayana Raju Yadati, Mekala Padmaja,Lalit Sankhe, Chhaya Rajguru,Monica Gupta,Govind Kumar,Minakshi Dhar,Jorge Jovicich,Andrea Ganna,Mary Ganguli,Prasun Chatterjee,Sunny Singhal,Rishav Bansal,Swati Bajpai,Gaurav Desai, Swaroop Bhatankar,Abhijith R Rao,Palanimuthu T Sivakumar,Krishna Prasad Muliyala,Preeti Sinha,Santosh Loganathan,Erik Meijer,Marco Angrisani,Jung Ki Kim,Sharmistha Dey,Perianayagam Arokiasamy,David E Bloom,Arthur W Toga,Sharon L R Kardia,Kenneth Langa,Eileen M Crimmins,Aparajit B Dey

Scientific data（2023）

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摘要

The Harmonized Diagnostic Assessment of Dementia for the Longitudinal Aging Study in India (LASI-DAD) is a nationally representative in-depth study of cognitive aging and dementia. We present a publicly available dataset of harmonized cognitive measures of 4,096 adults 60 years of age and older in India, collected across 18 states and union territories. Blood samples were obtained to carry out whole blood and serum-based assays. Results are included in a venous blood specimen datafile that can be linked to the Harmonized LASI-DAD dataset. A global screening array of 960 LASI-DAD respondents is also publicly available for download, in addition to neuroimaging data on 137 LASI-DAD participants. Altogether, these datasets provide comprehensive information on older adults in India that allow researchers to further understand risk factors associated with cognitive impairment and dementia.

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