RE-RANKING FOR PRIORITIZATION OF DISEASE-RELATED GENES

Lejun Gong,Ronggen Yang,Chun Zhang,Quan Liu, Huakang Lee,Geng Yang

BIOMEDICAL ENGINEERING-APPLICATIONS BASIS COMMUNICATIONS（2016）

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摘要

To explore the genetic complexity of disease, this paper focuses on the prioritization of susceptibility genes by re-ranking. This approach prioritizes disease-related genes based on the prior ranking. The genes in prior ranking are divided into seeds and candidates. And then these seed genes are used to prioritize candidates based on association rules. Experimental results show the approach is promising for finding new disease-related genes.

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关键词

Association rules,Text mining,Gene prioritization,Disease-related genes

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