MYCN controls an alternative RNA splicing program in high-risk metastatic neuroblastoma

Shile Zhang, Jun S. Wei,Samuel Q. Li, Tom C. Badgett,Young K. Song, Saurabh Agarwal,Cristian Coarfa, Catherine Tolman,Laura Hurd,Hongling Liao, Jianbin He, Xinyu Wen,Zhihui Liu, Carol J. Thiele,Frank Westermann, Shahab Asgharzadeh,Robert C. Seeger,John M. Maris, Jamie M. Guidry Auvil,Malcolm A. Smith

Cancer Letters（2016）

引用 38|浏览42

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摘要

•A characteristic isoform expression pattern is detected in MYCN-amplified NBL tumors.•Several splicing factors control the splicing program in NBL tumors.•MYCN directly controls the expression of splicing factors PTBP1 and HNRNPA1.•Splicing factors PTBP1 and HNRNPA1 and their downstream splicing target PKM2 affect MYCN-amplified NBL cell proliferation.

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关键词

NBL,pre-mRNA,MYCN-A,MYCN-NA,RNA-seq,PCA,DEG,DSG,ChIP-seq

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